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Updated: May 12, 2026

Crystal Structure of the N-terminal Domain of Ryanodine Receptor from Plutella xylostella
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Published on: November 30, 2018

在瑞诺丁受体内的突变相关的缺陷域间相互作用会导致异常的Ca2+释放,从而导致catecholaminergic多态心室性心跳动心

Takeshi Suetomi1, Masafumi Yano, Hitoshi Uchinoumi

  • 1Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Yamaguchi, 755-8505, Japan.

Circulation
|July 20, 2011
PubMed
概括

与RyR2相关的RyR2突变导致异常的RyR2通道激活. 这项研究表明,S2246L突变诱导了特定的域相互作用,导致Ca2+火花增加和致命性心律失常.

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