埃泽胺和植物对胆固醇代谢的联合作用:人类随机对照养研究
Xiaobo Lin1, Susan B Racette, Michael Lefevre
1Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Circulation
|July 20, 2011
概括
将植物醇添加到ezetimibe中可以显著改善胆固醇代谢,并降低LDL胆固醇. 这种组合疗法在治疗高胆固醇血症方面表现有前途.
科学领域:
- 心血管研究研究心血管研究
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 已知埃泽胺和植物可以抑制胆固醇的吸收.
- 这项研究研究了结合ezetimibe和植物的协同效应.
研究的目的:
- 为了测试这种假设,以塞蒂米布与植物结合在改变胆固醇代谢方面比单独的以塞蒂米布更有效.
- 评估对肠道胆固醇吸收,便胆固醇分泌和LDL胆固醇水平的影响.
主要方法:
- 一项随机,双盲,安慰剂控制,三重交叉研究,涉及21名轻度高胆固醇患者.
- 试验对象接受了控制饮食,每人服用埃泽蒂米布安慰剂+植物类安慰剂,埃泽蒂米布+植物类安慰剂或埃泽蒂米布+植物类安慰剂3周.
- 所有的食物都由代谢厨房提供,以确保饮食控制.
主要成果:
- 与单独使用ezetimibe和对照剂相比,联合使用ezetimibe和植物可以显著降低肠道胆固醇的吸收 (P<0.0001).
- 便中的胆固醇分泌量在联合治疗时显著增加 (P<0.0001).
- 血低密度脂蛋白胆固醇水平与对照组相比 (101 mg/dL与129 mg/dL;P<0.0001) 显著降低.
结论:
- 将植物醇添加到ezetimibe中显著增强了它对胆固醇代谢和降低LDL胆固醇的影响.
- 综合饮食和药理干预强调了植物醇作为高胆固醇血症辅助治疗的潜力.
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