在信息处理和社会功能障碍方面的新皮层激发/抑制平衡
Ofer Yizhar1, Lief E Fenno, Matthias Prigge
1Department of Bioengineering, Stanford University, Stanford, California, USA. ofer.yizhar@weizmann.ac.il
Nature
|July 29, 2011
概括
在大脑中增加了兴奋抑制 (E/I) 平衡.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 精神病学研究 精神病学研究
背景情况:
- 自闭症和精神分裂症的严重行为缺陷被假设是由于神经刺激-抑制 (E/I) 平衡的改变引起的.
- 这个假设统一了遗传和病理生理学数据,但缺乏直接的实验验证.
研究的目的:
- 使用新型光遗传学工具在体内因果调查E/I平衡假设.
- 探索与自由移动的哺乳动物中改变的E / I平衡相关的电路生理学.
主要方法:
- 开发和应用新的光遗传工具来精确操纵神经E/I平衡.
- 在小鼠体内电生理学记录和行为评估.
主要成果:
- 在小鼠中部前额叶皮层中提高E / I平衡,损害了细胞信息处理和诱导行为缺陷.
- 观察到高频功率 (30-80 Hz) 的增加,反映了人类临床发现.
- 抑制神经元刺激的补偿性增强部分挽救了社会赤字.
结论:
- 结果支持这样一个假设:细胞E/I平衡升高会导致严重的神经精神疾病症状.
- 光遗传学操纵提供了E / I平衡和行为障碍之间的因果关系.
- 这些发现提供了关于精神疾病背后的神经回路的见解.
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