一个受体向的有机金属 (II) 复合物的光控制的DNA结合
Flavia Barragán1, Paula López-Senín, Luca Salassa
1Departament de Química Orgànica and IBUB, Universitat de Barcelona, Spain.
Journal of the American Chemical Society
|July 30, 2011
概括
与瘤向酸相关的光活性复合物在暴露于光线时释放酸. 然后,释放的鲁物种与DNA发生反应,形成添加物,特别是与瓜基,表明有针对性癌症治疗的潜力.
科学领域:
- 有机金属化学 有机金属化学
- 生物有机化学 生物有机化学
- 摄影化学的使用.
背景情况:
- (II) 烯复合体在向治疗中具有潜力.
- 像八类同类和RGD三类的类可以准瘤细胞.
- 光激活提供了一种控制药物释放的机制.
研究的目的:
- 为了将可光激活的 (((II) 烯复合体与瘤向酸结合起来.
- 为了研究光诱导的的释放和随后的DNA相互作用.
- 探索这些复杂物在向癌症治疗中的潜力.
主要方法:
- -联体的合成和表征.
- 紫外线和NMR光谱学用于监测光解离.
- 光激活物种与DNA核基和寡核酸的反应.
主要成果:
- -联体在黑暗中是稳定的,但在暴露在光线下光解离.
- 释放的水生物种与DNA中的瓜基发生反应,形成添加物.
- 在DNA的存在下进行辐射可能会导致多牙的鲁添加物,涉及多个关氨酸.
结论:
- 光激活的 ((II) 烯复合物可以从向酸中选择性地释放出来.
- 被释放的物种对DNA,特别是关氨酸,表现出反应性.
- 这些发现表明,有可能开发用于癌症治疗的光激活向金属药物.
相关概念视频
01:26Photochemical Electrocyclic Reactions: Stereochemistry
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
Selection Rules: Photochemical Activation
02:51Metal-Ligand Bonds
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
01:23Properties of Organometallic Compounds
Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.