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Updated: May 30, 2026

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RNAi 查识别了 Brd4 作为急性髓性白血病的治疗点

Johannes Zuber1, Junwei Shi, Eric Wang

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

Nature
|August 5, 2011
PubMed
概括

研究人员确定含有odomain 4 (Brd4) 是急性髓性白血病 (AML) 的关键调节剂. 用JQ1抑制Brd4显示出显著的抗白血病作用,向癌症干细胞,并提供了一个有前途的治疗策略.

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