在吸血鬼蝙蝠的红外感觉的基础上,TRPV1的团特异性拼接是吸血鬼蝙蝠的基础
相关实验视频
Updated: May 5, 2026

07:50
Electrophysiology of Scorpion Peg Sensilla
Published on: April 13, 2011
12.4K
Elena O Gracheva1, Julio F Cordero-Morales, José A González-Carcacía
1Department of Physiology, University of California, San Francisco, California 94158-2517, USA.
Nature
|August 5, 2011
概括
吸血鬼蝙蝠通过修改的TRPV1通道检测红外辐射,降低其热敏度. 它们三神经中的这种独特的分子适应使它们能够找到温血的猎物.
科学领域:
- 分子生物学分子生物学
- 神经科学是一个神经科学.
- 进化生物学 进化生物学
背景情况:
- 吸血鬼蝙蝠具有独特的检测红外辐射以检测猎物的能力.
- 这种红外传感由由三角神经纤维透的专门的器官介导.
- 蝙蝠和某些蛇都进化了极端的热感觉,为热感受器进化提供了洞察力.
研究的目的:
- 为了研究吸血鬼蝙蝠中红外探测的基础分子机制.
- 了解吸血鬼蝙蝠如何调整热感应以定位猎物.
- 探索蝙蝠TRPV1通道适应的进化基础.
主要方法:
- 在吸血鬼蝙蝠三角性中分析TRPV1基因和转录变异.
- 蝙蝠和其他Laurasiatheria哺乳动物中TRPV1基因组织的比较.
- TRPV1通道变体的功能性特征.
主要成果:
- 吸血鬼蝙蝠利用一个已经敏感于热量的通道,TRPV1,用于红外探测.
- 在三腺中TRPV1转录的替代拼接将其激活值降低到大约30°C.
- 这种拼接特别发生在三腺中,保留了TRPV1在检测其他地方有害热量的作用.
- 蝙蝠Trpv1基因组织在Laurasiatheria哺乳动物中保存,这表明它们有共同的进化历史.
结论:
- 吸血蝙蝠通过替代拼接来修改TRPV1通道进化了红外传感.
- 这种分子机制代表了调整热感应神经纤维的新策略.
- 这些发现突显了热受体的进化可塑性,并提供了关于蝙蝠特定适应性的见解.
相关概念视频
Thermosensation
29.7K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
29.7K
Mechanically-gated Ion Channels
6.6K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.6K
G-Protein Gated Ion Channels
5.5K
GPCRs are primarily responsible for our sense of smell, taste, and vision. The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
Sensory...
5.5K
Introduction to Sensory Receptors
9.1K
Sensory receptors are vital in our ability to perceive and interpret the world. Sensory receptors are specialized cells in the peripheral nervous system that respond to various stimuli and enable one to experience different sensations. Based on specific criteria, sensory receptors are classified into distinct types.
The first classification criterion is based on cell type, position, and function. Some receptor cells are neurons with free nerve endings, where their dendrites are embedded in the...
The first classification criterion is based on cell type, position, and function. Some receptor cells are neurons with free nerve endings, where their dendrites are embedded in the...
9.1K
Introduction to Special Senses
6.8K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
6.8K
The Physiology of Taste
6.8K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
6.8K

