从富含ACHC的β-酸中形成的轻热液晶
William C Pomerantz1, Virany M Yuwono, Ryan Drake
1Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Journal of the American Chemical Society
|August 6, 2011
概括
修改β-,这是螺旋分子,影响它们形成液晶 (LC) 阶段的能力. 特定的结构变化可以大大改变LC相形成,导致设计新的LC形成.
科学领域:
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
- 超分子化学 超分子化学
背景情况:
- β-是一种具有自我组装潜力的螺旋分子.
- 热液晶 (LC) 阶段是溶液中形成的有序的流体结构.
- 了解结构属性关系是设计自组装的关键.
研究的目的:
- 调查β-结构的修改如何影响它们在水中形成溶性液晶 (LC) 阶段的能力.
- 探索残留物类型,电荷分布和终端组对LC相形成的影响.
- 设计新的LC形成β-,结合生物分子识别动机.
主要方法:
- 合成和修改含有转2-氨基氨基环氧碳酸 (ACHC) 的10余β-.
- ACHC含量,充电模式和终端组的系统变化.
- 使用循环二重化 (CD) 和冷传输电子显微镜 (cryo-TEM) 分析自组装.
主要成果:
- 微小的结构变化,如电荷交换,可以显著抑制LC相形成.
- 用生物素或Arg-Gly-Asp图案设计的β-酸成功形成了LC相.
- 观察到两种类型的自我关联结构:球状聚合物和纳米纤维.
- 纳米纤维被确定为LC阶段形成中的主要中原体.
结论:
- 贝塔-序列和结构批判性地控制了溶性流体晶体相的形成.
- β-的模块性允许合理设计自组装材料.
- 纳米纤维代表了这些系统中驱动LC阶段行为的关键结构单元.
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