在Drosophila的营养限制期间,无细胞淋巴瘤激酶节省了器官生长
Louise Y Cheng1, Andrew P Bailey, Sally J Leevers
1Division of Developmental Neurobiology, Medical Research Council National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.
Cell
|August 6, 2011
概括
发育中的动物在饥饿期间保护关键器官的生长. 在Drosophila中,形淋巴瘤激酶 (Alk) 通过调节营养感应和PI3-激酶信号传递来节省中枢神经系统 (CNS) 的生长.
科学领域:
- 发展生物学 发展生物学
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- 在饥饿期间,发育中的动物优先考虑关键器官的生长.
- 在营养限制 (NR) 期间,中央神经系统 (CNS) 最好不受影响.
- 在饥饿中调节特权组织生长的机制在很大程度上是未知的.
研究的目的:
- 为了研究Drosophila在营养限制期间的脑节约背后的分子机制.
- 阐明形淋巴瘤激酶 (Alk) 在保护神经前体生长中的作用.
主要方法:
- 使用Drosophila melanogaster作为一个模型生物.
- 研究了形淋巴瘤激酶 (Alk) 和其信号通路 (Slimfast/Rheb/TOR复合体1,PI3-激酶) 的功能.
- 检查了在质细胞利基中的Alk连接体Jelly belly (Jeb) 的表达.
主要成果:
- 证实,在Drosophila的NR过程中,中枢神经系统比其他组织更容易受到保护.
- 证明Alk在NR期间保护神经细胞生长免受营养和胰岛素类的减少.
- 显示Alk抑制了氨基酸感应需求,主要激活PI3-激酶信号传递.
- 鉴定出质细胞的构成性Jeb表达对介导PI3-激酶维护至关重要.
结论:
- 无塑性淋巴瘤激酶 (Alk) 在Drosophila的饥饿期间在脑节省中发挥着关键作用.
- 阿尔克采用双重机制,在营养限制下维持神经细胞生长.
- 这项研究揭示了一种保存的大脑节约机制,这对理解抗饥饿癌症的瘤生长有意义.
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