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Updated: May 30, 2026

Preparation of Meiotic Chromosome Spreads from Mouse Oocytes for Assessment of Synapsis and Recombination
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保护重复的DNA边界免受自我诱导的介质不稳定

Gerben Vader1, Hannah G Blitzblau, Mihoko A Tame

  • 1Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Nature
|August 9, 2011
PubMed
概括

在重复的DNA序列中,DNA双链断裂 (DSBs) 在半变异过程中构成风险. 酵母研究表明,rDNA阵列边界易受DSB的感染,需要特殊的保护,以防止基因组不稳定性和与疾病相关的重排.

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