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Updated: May 30, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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通过固态NMR光谱学探测的Y145Stop人类蛋白粉样蛋白纤维的分子间对齐

Jonathan J Helmus1, Krystyna Surewicz, Marcin I Apostol

  • 1Department of Chemistry, The Ohio State University, Columbus, 43210, United States.

Journal of the American Chemical Society
|August 11, 2011
PubMed
概括

人类质蛋白的Y145Stop突变体形成了粉样纤维,并有一个平行在注册表中的β-sheet核心. 这一发现促进了对蛋白粉样蛋白结构和疾病机制的理解.

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