Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function04:05

A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function

748
Here we present a protocol for a versatile behavior test developed recently, the ladder beam test. This test has the advantage of detecting subtle cerebellar ataxia caused by a defect of thyroid hormone action in the central nervous system over the conventional behavior tests assessing motor performance.
748
In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse04:14

In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

1.2K
The Thyroid Hormone Action Indicator mouse model was developed to enable tissue-specific quantification of local thyroid hormone action using its endogenous regulatory machinery. Recently, it has been shown that the model is suitable for characterizing endocrine-disrupting chemicals interacting with thyroid hormone economy, both by ex vivo and in vivo...
1.2K
An Ex vivo Model to Study Hormone Action in the Human Breast12:31

An Ex vivo Model to Study Hormone Action in the Human Breast

12.0K
We have developed a novel ex vivo model to study hormone action in the human breast. It is based on tissue microstructures isolated from surgical breast tissue specimens which preserve tissue architecture, intercellular interactions, and paracrine...
12.0K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.0K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.2K
Secondary Messengers in Hormone Action01:26

Secondary Messengers in Hormone Action

4.7K
Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
4.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Quantitative assessment of pituitary resistance to thyroid hormone from plots of the logarithm of thyrotropin versus serum free thyroxine index.

The Journal of clinical endocrinology and metabolism·2000
Same author

Evolving concepts of thyroid hormone action.

Biochimie·1999
Same author

Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) modulates expression of the Purkinje cell protein-2 gene. A potential role for COUP-TF in repressing premature thyroid hormone action in the developing brain.

The Journal of biological chemistry·1998
Same author

Beta receptor isoforms are not essential for thyroid hormone-dependent acceleration of PCP-2 and myelin basic protein gene expression in the developing brains of neonatal mice.

Molecular and cellular endocrinology·1998
Same author

Lack of effect of thyroid hormone on late fetal rat brain development.

Endocrinology·1997
Same author

Molecular basis of thyroid hormone-dependent brain development.

Endocrine reviews·1997
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
查看所有相关文章

相关实验视频

Updated: Jan 20, 2026

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

748

甲状腺激素在细胞水平的作用.

J H Oppenheimer

    Science (New York, N.Y.)
    |March 9, 1979
    PubMed
    概括
    此摘要是机器生成的。

    甲状腺激素的作用涉及一个核受体综合体,该综合体调节信使RNA (mRNA) 合成. 细胞对这种复合物的敏感性,而不是受体数量,似乎是甲状腺激素反应的关键.

    更多相关视频

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
    04:14

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

    Published on: October 6, 2023

    1.2K
    An Ex vivo Model to Study Hormone Action in the Human Breast
    12:31

    An Ex vivo Model to Study Hormone Action in the Human Breast

    Published on: January 8, 2015

    12.0K

    相关实验视频

    Last Updated: Jan 20, 2026

    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
    04:05

    Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

    Published on: October 6, 2023

    748
    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
    04:14

    Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

    Published on: October 6, 2023

    1.2K
    An Ex vivo Model to Study Hormone Action in the Human Breast
    12:31

    An Ex vivo Model to Study Hormone Action in the Human Breast

    Published on: January 8, 2015

    12.0K

    科学领域:

    • 分子内分泌学分子内分泌学
    • 基因规则 基因规则
    • 细胞生物学 细胞生物学

    背景情况:

    • 甲状腺激素的细胞作用是由核受体复合体介导的.
    • 这种复合物影响各种信使RNA (mRNA) 序列的产生.

    研究的目的:

    • 探索甲状腺激素在细胞水平作用的调节机制.
    • 为了研究三氨酸核受体复合体在基因表达中的作用.

    主要方法:

    • 在对甲状腺激素的反应中分析mRNA序列的变化.
    • 检查细胞对triiodothyronine核受体复合物的敏感性.

    主要成果:

    • 有证据表明,triiodothyronine核受体综合体是甲状腺激素作用的基本单元.
    • 观察到mRNA水平的普遍和特定增加.
    • 细胞调节发生在局部,敏感性可能在后受体水平上调节.

    结论:

    • 甲状腺激素的作用在细胞内局部调节,可能在受体后部位.
    • 对三甲氨酸核受体复合体敏感性的选择性改变发生在特定的目标基因中.
    • 受体位数不是甲状腺激素反应的可靠指标.