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Updated: May 30, 2026

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
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Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

α-Synuclein在生理上以螺旋式折叠的四聚体形式发生,它抵抗聚合

Tim Bartels1, Joanna G Choi, Dennis J Selkoe

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|August 16, 2011
PubMed
概括

帕金森病涉及错误折叠的α-synuclein (α-synuclein). 帕金森病包括错误折叠的α-synuclein (α-synuclein). 这项研究揭示了内源性α-synuclein形成稳定的四聚体,而不是单聚体,这表明四聚体稳定可能会预防帕金森病的病理.

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