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相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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相关实验视频

Updated: May 30, 2026

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
06:42

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

记忆CD4+和CD8+T细胞通过外围迁移的不同模式.

Thomas Gebhardt1, Paul G Whitney, Ali Zaid

  • 1Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia. gebhardt@unimelb.edu.au

Nature
|August 16, 2011
PubMed
概括

记忆 CD4 ((+) 和 CD8 ((+) T 细胞在皮肤感染后表现出不同的迁移模式. CD8 ((+) T细胞保持局部化,而CD4 ((+) T细胞重新循环,影响周围免疫监测和局部免疫力.

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Human T Lymphocyte Isolation, Culture and Analysis of Migration In Vitro
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Human T Lymphocyte Isolation, Culture and Analysis of Migration In Vitro

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Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

相关实验视频

Last Updated: May 30, 2026

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
06:42

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

Human T Lymphocyte Isolation, Culture and Analysis of Migration In Vitro
08:39

Human T Lymphocyte Isolation, Culture and Analysis of Migration In Vitro

Published on: June 1, 2010

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 病毒学 病毒学

背景情况:

  • 周围组织感染主要T细胞对病原体控制的反应.
  • 记忆T细胞,包括迁移和定居种群,对于病原体进入地点的长期免疫是至关重要的.
  • 对于CD4 ((+) 辅助T细胞和CD8 ((+) 杀伤性T细胞,存在不同的编程要求.

研究的目的:

  • 调查皮肤感染后记忆CD4 ((+) 和CD8 ((+) T细胞之间的迁移和组织定位的差异.
  • 探索这些子集在周边免疫监测和局部感染控制中的作用.

主要方法:

  • 利用小鼠模型研究疹简单病毒皮肤感染后的T细胞反应.
  • 分析了病毒特异性记忆CD4 ((+) 和CD8 ((+) T细胞感染后的迁移模式和组织定位.
  • 检查了T细胞子集上的指导分子表达.

主要成果:

  • 在感染后的皮肤中确定了两种不同的记忆T细胞子集:表皮中的被隔离的,常驻的CD8 (((+) T细胞和皮肤中的动态的,循环的CD4 (((+) T细胞.
  • 观察到CD8(+) T细胞在很大程度上局限于原始感染部位.
  • 证明CD4 ((+) T细胞通过皮肤迅速运输,表明了更广泛的循环模式.
  • 在CD4上发现独特的同源分子表达 (((+) 与它们的迁移能力相关的T效应器-记忆细胞.

结论:

  • 突出了记忆CD4 ((+) 和CD8 ((+) T细胞的迁移和组织定位的显著差异.
  • 揭示了以前不被赞赏的记忆T细胞迁移中的复杂性.
  • 基于它们的迁移行为,在外周免疫力中建议CD4 ((+) 和CD8 ((+) T细胞具有不同的功能作用.