n-3多不和脂肪酸在预防心脏转动后心房的复发:一个前性随机研究
Savina Nodari1, Marco Triggiani, Umberto Campia
1Department of Experimental and Applied Medicine, Section of Cardiovascular Diseases, University of Brescia Medical School, P. le Spedali Civili, 1-25123 Brescia, Italy.
Circulation
|August 17, 2011
概括
欧米茄-3脂肪酸 (n-3PUFA) 在患有持续性心房的患者中显著改善了鼻节律的维持. 这一发现表明n-3PUFA可能有助于预防心房的复发.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 营养科学 营养科学
背景情况:
- 欧米茄-3多不和脂肪酸 (n-3PUFA) 已知具有抗心律失常的特性,但它们在预防心房动 (AF) 的有效性仍有争议.
- 持久性AF管理通常涉及阿米奥达龙和氨酸-血管酶-氨系统 (RAAS) 抑制剂.
研究的目的:
- 评估n-3PUFA对维持心转动后鼻节律的影响,在已经服用阿米奥达龙和RAAS抑制剂的持久性AF患者中.
- 为了确定n-3PUFA是否可以改善AF复发率.
主要方法:
- 进行了一项随机,双盲,安慰剂控制的试验.
- 199名患有持续性AF的患者,接受阿米奥达龙和RAAS抑制剂治疗,随机分配给接受n-3PUFA (2g/d) 或安慰剂.
- 在随机化后4周进行了直流心脏转换,在1年后评估了鼻节律的维持.
主要成果:
- 与安慰剂组相比,在n-3PUFA组中,在1年内维持鼻节律的概率明显高于安慰剂组.
- 在n-3PUFA组中,维持鼻节律的危险比为0.62 (95% CI,0.52至0.72).
- P值为0.0001,表明了统计学意义.
结论:
- 将n-3PUFA (2g/d) 添加到阿米奥达龙和RAAS抑制剂中,可以在持续性AF患者心转动后增强鼻节律的维持.
- 这些发现表明n-3PUFA在预防AF复发方面可能发挥作用.
- 建议进行进一步的研究来验证和扩大这些结果.
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