用血管内高频超声波对冠状动脉进行成像
B N Potkin1, A L Bartorelli, J M Gessert
1Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892.
血管内超声波 (IVUS) 准确地描绘出冠状动脉动脉样硬化,与光膜大小和斑块厚度的组织学相关性良好. 这项技术在诊断冠状动脉疾病和指导干预方面表现有前途.
科学领域:
- 心血管成像 - 心血管成像
- 医学超声波 医学超声波
- 干预心脏病学 干预心脏病学
背景情况:
- 对动脉样硬化冠状动脉进行精确的成像对于新的干预疗法至关重要.
- 导管式血管内超声波 (IVUS) 是冠状动脉的潜在成像方式.
研究的目的:
- 为了确定小型原型IVUS系统成像动脉样硬化冠状动脉的可靠性.
- 为了比较IVUS成像与冠状动脉截面的组织学分析.
主要方法:
- 一个1毫米的传感器,25MHz的IVUS原型被用来成像21个人类冠状动脉中度至重度动脉样硬化.
- 通过数字视频平面测量,将54个动脉样硬化部位与甲固定和新鲜的组织学截面进行了比较.
- 测量包括横截面积,光量面积,百分比面积和墙壁厚度.
主要成果:
- IVUS测量结果与横截面积 (r=0.94),光线面积 (r=0.85),百分比面积 (r=0.84) 和壁厚 (r=0.92) 的组织学数据有很高的相关性.
- 在96%的病例中,IVUS准确预测了组织学斑块组成.
- 独特的声谱特征允许分辨化,纤维化和富含脂质的斑块.
结论:
- 血管内超声波可以准确地描述冠状动脉光线,壁面几何和动脉样斑块.
- IVUS具有显著的潜力,可以提高冠状动脉样硬化的诊断.
- 这种成像模式可能指导冠状动脉疾病的新型导管治疗方法.
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