养的Caenorhabditis物种的并行进化目标是费洛蒙受体基因
Patrick T McGrath1, Yifan Xu, Michael Ailion
1Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behavior, The Rockefeller University, New York, New York 10065, USA.
Nature
|August 19, 2011
概括
在Caenorhabditis线虫中,高密度的生长驱动了费罗蒙受体基因的可再生遗传变化,导致了适应. 受体基因的这种并行进化影响了物种之间的生命史特征.
科学领域:
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
- 遗体学 遗体学 是一个学科.
背景情况:
- 环境变化可以推动可预测的进化轨迹.
- 同特定的相互作用在动物环境中代表着显著的选择性压力.
- 高密度生长条件在家庭环境中很常见,可以影响适应.
研究的目的:
- 调查Caenorhabditis物种适应高密度生长的遗传基础.
- 识别与适应特定环境压力相关的可再生遗传变化.
- 了解费洛蒙受体基因在生命史特征演化中的作用.
主要方法:
- 适应高密度的Caenorhabditis elegans和Caenorhabditis briggsae菌株的比较基因组学.
- 对费洛蒙受体基因 (蛇形受体类g-srg) 缺失的遗传分析.
- 错误表达实验以确定srg基因在费洛蒙反应中的功能.
主要成果:
- 两个独立的Caenorhabditis elegans菌株在高密度下获得了对费洛蒙诱导的多基因耐药性.
- 在C. elegans中的耐药性是由破坏srg-36和srg-37的删除引起的,这些删除对糖酸C3.3的冗余受体进行编码.
- 凯诺哈比迪斯布里格萨也通过删除相似的srg基因而产生了耐药性.
结论:
- 高密度适应涉及化学受体谱的快速重塑.
- 在srg基因的并行遗传变化有助于跨Caenorhabditis物种的适应.
- 进化适应环境条件可能涉及影响生命历史特征的并行遗传变化.
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