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展开的蛋白质是Ire1-激活连接体,直接诱导展开的蛋白质反应

Brooke M Gardner1, Peter Walter

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|August 20, 2011
PubMed
概括

展开的蛋白质反应 (UPR) 被激活时,内细胞网膜 (ER) 蛋白 Ire1 直接与展开的蛋白质结合. 这种由特定的氨基酸残留物介导的结合触发了Ire1的寡合化和UPR的激活.

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