在脊椎动物进化过程中,有三个监管创新时期
Craig B Lowe1, Manolis Kellis, Adam Siepel
1Center for Biomolecular Science and Engineering, University of California, Santa Cruz, CA 95064, USA.
概括
基因调节元件的进化表明了不同的创新时期. 早期在发育基因附近的收获转移到脊椎动物的细胞外信号和蛋白质修饰基因.
科学领域:
- 进化基因组学是进化的基因组学.
- 基因调节 基因调节
- 脊椎动物的进化过程
背景情况:
- 基因调节元件的变化推动了跨动物血统的表型进化.
- 了解监管要素的起源和演变对于破译进化过程至关重要.
研究的目的:
- 为了研究在脊椎动物进化过程中基因调节元素的增加.
- 识别整个基因组的假定调节区域集,并推断它们的进化起源.
主要方法:
- 确定了保存的非基元素 (CNEEs) 作为五种脊椎动物基因组的假定调节区域,包括人类.
- 推断出CNEE受到选择性约束的进化分支.
主要成果:
- 在脊椎动物进化过程中发现了三个不同的调节元素创新的时期.
- 早期的脊椎动物进化在转录因子和发育基因附近具有调节性收益.
- 后来的时期显示出细胞外信号传递和翻译后蛋白质修饰基因附近的创新.
结论:
- 基因调节元件的进化是由它们关联的基因类型的动态变化所表现的.
- 这些转变反映了脊椎动物系的主要进化过渡和适应.
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