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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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有效地发现了针对HIV逆转录酶的Tyr181Cys变体的强效抗HIV药物

William L Jorgensen1, Mariela Bollini, Vinay V Thakur

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States. william.jorgensen@yale.edu

Journal of the American Chemical Society
|August 23, 2011
PubMed
概括

新的非核类逆转录酶抑制剂 (NNRTIs) 克服了HIV-1抗性突变. 计算机建模指导了对野生型和突变的HIV菌株有效的强效NNRTIs的设计.

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