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相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Fischer Projections02:18

Fischer Projections

Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
Biosynthesis of Polysaccharides01:26

Biosynthesis of Polysaccharides

Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
Chemistry of Carbohydrates03:25

Chemistry of Carbohydrates

Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...

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相关实验视频

Updated: May 30, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

搜索和优化结构组合复杂的柔性糖的结构组合.

Junchao Xia1, Claudio J Margulis, David A Case

  • 1BioMaPS Institute and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey 08854, United States. junchao-xia@biomaps.rutgers.edu

Journal of the American Chemical Society
|August 26, 2011
PubMed
概括
此摘要是机器生成的。

核磁共振 (NMR) 方法现在可以通过分析灵活的碳水化合物对象组合来确定分子几何. 这项研究引入了一种新的计算方法,以准确权重这些对母乳糖的符合者.

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Last Updated: May 30, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

Interactive Molecular Model Assembly with 3D Printing
06:15

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Published on: August 13, 2020

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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科学领域:

  • 碳水化合物的化学成分
  • 结构生物学是结构生物学.
  • 计算化学是一种计算化学.

背景情况:

  • 核磁共振 (NMR) 限制通常用于分子几何学确定,当单一的低能度构造占主导地位时.
  • 像碳水化合物这样的灵活分子通常存在于低能变态组合中,这使得使用NMR进行直接结构分析变得复杂.
  • 剩余二极合 (RDC) 和标量合是对分子构造敏感的NMR可观测物.

研究的目的:

  • 开发和验证一种新的计算程序,用于在集体内识别和权衡符合性贡献.
  • 将这种方法应用于母乳寡糖,以确定它们的构造群.
  • 为了评估基因组血型表征中的葡萄糖结的刚性.

主要方法:

  • 利用遗传算法,在计算和实验RDC之间将R因子最小化.
  • 采用快速糖结构预测软件 (FSPS) 进行详尽的局部最小值结构性搜索.
  • 基于与RDC和标量合器等NMR可观测值的比较,优化了对应器重量.

主要成果:

  • 成功地将框架应用于六种母乳糖 (LND-1,LNF-1,LNF-2,LNF-3,LNnT,LNT).
  • 对于每个糖类的合规组合,确定了种群重量.
  • 证明了RDCs可以准确地通过一小部分主导符合的子集来表示.

结论:

  • 开发的程序有效地使用NMR数据建模灵活碳水化合物的构造组合.
  • 几个关键符合者足以代表研究的人类牛奶糖的RDC.
  • 结果表明,在几种,但并非所有,在血型组表征体内的甘氨酸链接中存在显著的刚性.