衰老的系统环境对神经发生和认知功能有负面调节
Saul A Villeda1, Jian Luo, Kira I Mosher
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
Nature
|September 3, 2011
概括
老龄化会影响大脑干细胞活动和记忆力. 来自老老鼠的血液因子会降低年轻小鼠的神经发生和认知功能,将CCL11确定为关键分子. 这表明血液传递的因素有助于与年龄相关的认知衰退.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 干细胞生物学 干细胞生物学
背景情况:
- 衰老导致神经干细胞/原始细胞的减少和中枢神经系统的神经发生.
- 认知功能随着年龄的增长而下降,但可以通过炼等因素来改善.
- 系统性因素在与年龄相关的神经生成衰退中的作用尚未完全理解.
研究的目的:
- 以年龄依赖的方式调查系统性,血液传递因素对成人神经发生和认知功能的影响.
- 为了确定血液中影响神经发生和老化过程中的学习的特定分子.
主要方法:
- 在小鼠中研究年轻和老的系统环境的影响.
- 评估突触可塑性,情境恐惧条件化,空间学习和记忆.
- 测量血和脑脊液中的化学激素水平,特别是CCL11 (eotaxin).
- 在体内操纵年轻小鼠的CCL11水平.
主要成果:
- 暴露于旧的系统环境或老老鼠血会降低年轻小鼠的神经发生,突触可塑性和认知能力.
- 血中化学物质CCL11的水平与对象动物和老年小鼠的神经生成的减少有关.
- 在健康老年人的血和脑脊液中,CCL11水平升高.
- 在年轻小鼠中增加了外围CCL11,减少了神经发生和学习和记忆障碍.
结论:
- 系统环境中的血液传递因素可以以年龄依赖的方式抑制成年人的神经发生.
- 化学物质CCL11被确定为一种关键的血液传播因子,有助于与年龄相关的神经发生和认知功能下降.
- 这些发现表明,准血液传播因素可能为与年龄相关的认知障碍提供治疗策略.
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