对鸟类数字的转录组分析揭示了鸟类的保存和衍生数字身份
Zhe Wang1, Rebecca L Young, Huiling Xue
1Yale Systems Biology Institute, and Department of Ecology and Evolutionary Biology, Yale University, West Haven, Connecticut 06516, USA.
Nature
|September 6, 2011
概括
转录数据揭示了鸟类翅膀数字的身份,这表明第一个翅膀数字是从位置1进化而来的,而不是2. 这项研究阐明了鸟类四肢发育的进化途径.
科学领域:
- 进化生物学 进化生物学
- 发展遗传学 发展遗传学
- 进行比较基因组学.
背景情况:
- 形态特征源于发育过程中的基因表达.
- 了解鸟类翅膀的数字身份是一个长期存在的进化难题.
- 胚胎学和古生物学数据提供了有关鸟类数字起源的相互矛盾的证据.
研究的目的:
- 通过转录组数据来解决鸟类翅膀数字的身份.
- 为了研究鸟类肢体发育的进化历史.
- 为了比较鸟类翅膀和脚之间的基因表达模式.
主要方法:
- 对鸟类翅膀和脚部的指纹进行比较的转录分析.
- 使用全基因组基因表达数据来推断角色身份.
- 分析基因调节网络的数字发展的基础.
主要成果:
- 转录数据强烈地将第一个翅膀数字与第一个脚数字联系起来.
- 第一个翅膀数字,尽管从位置2发展,显示保存的身份与数字I.
- 后翼数字与后肢数字相比,表现出更高的差异化,表明独特的身份.
结论:
- 鸟类翅膀数字的身份可以通过基因表达模式追溯.
- 有证据表明,在鸟类干系中,第一个数字从1位转移到2位.
- 这项研究为鸟类数字身份提供了新的见解,挑战了现有的进化模型.
相关概念视频
Convergent Evolution
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
Multi-species Conserved Sequences
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Cis-regulatory Sequences
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Position-effect Variegation
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Gene Duplication and Divergence
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.


