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Updated: May 29, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
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Published on: October 2, 2018

结合稳定的cystathionine桥梁的α-Conotoxin ImI保持了充分的功效和相同的三维结构

Zoltan Dekan1, Irina Vetter, Norelle L Daly

  • 1Institute for Molecular Bioscience, The University of Queensland, St Lucia 4072, Queensland, Australia.

Journal of the American Chemical Society
|September 9, 2011
PubMed
概括

研究人员用稳定的硫乙烯替换了α-conotoxin ImI中的二硫化键. 一种类似物在α7尼古丁乙胆受体 (nAChR) 中保持了完全的对抗活性,显示出药物开发的潜力.

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