心脏病可能是肺栓塞的危险因素,而不是外周深静脉血栓形成
Henrik T Sørensen1, Erzsebet Horvath-Puho, Timothy L Lash
1Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, DK-8200 Aarhus N, Denmark. hts@dce.au.dk
Circulation
|September 9, 2011
概括
心脏病显著增加了肺栓塞 (PE) 的风险,而没有同时发生深静脉血栓塞 (DVT). 这项研究证实了先前的心脏事件和孤立的PE之间的强烈关联,突出了重要的临床考虑.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 流行病学 流行病学
背景情况:
- 心脏病是动脉栓塞的已知危险因素.
- 心脏病和肺栓塞 (PE) 之间的关联,特别是没有外周静脉血栓 (PVT),需要进一步澄清.
研究的目的:
- 调查前期心脏病与肺栓塞风险之间的关系,特别是孤立的PE.
- 在有心脏病史的患者中量化PE和深静脉血栓症 (DVT) 的风险.
主要方法:
- 在丹麦进行了一项全国性,基于人口的病例控制研究.
- 1980-2007年的数据包括被诊断患有PE和/或DVT的患者,人口对照.
- 几率比率被计算出来,以评估先前心脏病的相对风险,与不同的静脉血栓栓塞结局.
主要成果:
- 前3个月内心肌梗塞和心力衰竭显著增加了孤立PE的风险 (分别为43.5和32.4的OR).
- 与单独的PE相比,联合PE和DVT以及单独的DVT的风险较低.
- 右侧膜疾病显示PE的几率比左侧 (13.5) 高得多 (74.6).
结论:
- 心脏病大大增加了肺栓塞的短期风险.
- 在没有被诊断为外周静脉血栓症的情况下发生的PE的风险特别高.
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