患慢性阻塞性肺病的终身风险:一项纵向人口研究
Andrea S Gershon1, Laura Warner, Paul Cascagnette
1Institute for Clinical Evaluative Sciences, Toronto, ON, Canada. andrea.gershon@ices.on.ca
Lancet (London, England)
|September 13, 2011
概括
大约有27.6%的人在一生中被诊断出患有慢性阻塞性肺病 (COPD). 这项研究量化了北美不同人口群体的COPD风险.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 慢性阻塞性肺病 (COPD) 是导致死亡的主要原因,患病率高,医疗费用高.
- 在此之前,对于一般人群中COPD的综合性终身风险估计并不存在.
研究的目的:
- 为了量化患上医生诊断的慢性肺炎的终身风险.
- 分析大量多元文化北美人口中的COPD风险.
主要方法:
- 使用加拿大安大略省卫生行政数据进行的回顾性纵向队列研究 (大约. 有1300万个个体).
- 对1996年无COPD的个人进行长达14年的COPD诊断,80岁或死亡的监测.
- 利用基于医疗服务索赔的COPD验证病例定义,并对累积发病率进行修改的生存分析,并根据竞争风险进行调整.
主要成果:
- 在80岁时,医生诊断的COPD的终身总体风险为27.6%.
- 终身风险因人口统计学因素而异:男性 (29.7%) 与女性 (25.6%) 较高,社会经济地位较低 (32.1%) 与较高 (23.0%),农村 (32.4%) 与城市 (26.7%) 较高.
- 在研究期间,共有579,466人接受了COPD诊断.
结论:
- 几乎四分之一的人在一生中面临COPD诊断.
- 强调需要基于证据的临床策略,公共卫生倡议和进一步研究,以预防COPD并改善患者的生活质量.
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