对慢性阻塞性肺病免疫学的新见解
Guy G Brusselle1, Guy F Joos, Ken R Bracke
1Laboratory for Translational Research of Obstructive Pulmonary Disease, Department of Respiratory Medicine, Ghent University Hospital and Ghent University, Ghent, Belgium. guy.brusselle@ugent.be
Lancet (London, England)
|September 13, 2011
概括
慢性阻塞性肺病 (COPD) 涉及吸入刺激物引起的肺炎. 由于自身免疫和氧化应激等因素,即使在戒烟后,免疫反应也会持续下去.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 细胞生物学 细胞生物学
背景情况:
- 慢性阻塞性肺病 (COPD) 的特点是慢性肺炎.
- 有害的粒子和气体,主要是香烟烟雾,激活天生的免疫细胞.
- 这种激活会触发适应性免疫反应,导致肺组织发生变化.
研究的目的:
- 探索导致COPD持续性肺炎的机制.
- 了解各种因素在COPD病原发生中的作用,尽管戒烟.
主要方法:
- 关于COPD病原学的当前文献的综述.
- 免疫细胞激活通路的分析 (先天性和适应性).
- 讨论导致慢性炎症的因素.
主要成果:
- 香烟烟雾通过模式识别受体激活上皮细胞和巨细胞.
- 树突细胞启动适应性免疫,包括T细胞和B细胞反应.
- 感染会在稳定的COPD中放大并延续炎症.
结论:
- 慢性肺炎的持续性炎症是多因素的.
- 诸如自身免疫力,氧化应激,缺氧和微RNA失调等因素有助于.
- 这些因素使得即使在戒烟后,肺部炎症仍然存在.
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