在家族性高胆固醇血症中怀孕结果:基于注册表的研究
Ieva Toleikyte1, Kjetil Retterstøl, Trond Paul Leren
1Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway.
Circulation
|September 14, 2011
概括
患有家族性高胆固醇血症 (FH) 的女性不会面临早产,低出生体重或先天性缺陷的风险增加. 这项研究发现与一般人群相比没有显著差异.
科学领域:
- 心血管遗传学 心血管遗传学
- 生殖健康 生殖健康
- 临床流行病学临床流行病学
背景情况:
- 家族性高胆固醇血症 (FH) 显著增加女性心血管疾病的风险.
- 对于FH对怀孕和分娩结果的影响在很大程度上仍未得到研究.
- 了解这些风险对于在生育年龄的妇女中管理FH至关重要.
研究的目的:
- 为了研究异性FH和不良妊娠结果之间的关联.
- 为了比较早产,低出生体重和FH妇女与普通人口的先天性缺陷的风险.
- 为了为患有FH的孕妇提供临床指南.
主要方法:
- 利用了来自医学遗传学实验室和挪威医学出生登记 (1967-2006) 的链接数据.
- 包括1093名异卵性FH妇女和大约200万名来自普通人口的分娩.
- 分析出生结果,包括早产,低出生体重和先天性形.
主要成果:
- 在FH女性中,早产,低出生体重和先天性形的频率分别为6.8%,5.0%和3.3%.
- 在一般人群中,相应的频率分别为6.2%,5.2%和3.2%.
- 在FH女性中,不良结果的几率比率是无意义的 (早产:1.11,低出生体重:0.96,发育不良:1.09).
结论:
- 患有FH的妇女在统计学上没有显著的高风险出现早产,低出生体重婴儿或先天性形.
- 结果表明FH可能不会对这些特定的怀孕和分娩结果产生不利影响.
- 不能完全排除潜在的未被检测到的偏差,因此需要谨慎解释.
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