带有两个微型植入式辅助设备的双胞胎循环支持
Thomas Krabatsch1, Evgenij Potapov, Alexander Stepanenko
1Deutsches Herzzentrum Berlin, Department of Cardiovascular and Thoracic Surgery, Augustenburger Platz 1, D-13353 Berlin, Germany. krabatsch@dhzb.de
Circulation
|September 14, 2011
概括
两个可植入的离心心 HeartWare HVAD 可以有效地支持患有双心室性心力衰竭的患者. 这种新的双心室辅助系统与传统设备相比,可以提高患者的流动性和生活质量.
科学领域:
- 心血管外科心血管外科
- 医疗器械 医疗器械
- 心脏衰竭管理的管理
背景情况:
- 双性衰竭影响到30%的末期心力衰竭患者.
- 现有的双心室机械支选项 (例如,全人工心脏) 限制了患者的生活质量.
- 存在对更少侵入性和更舒适的双心室辅助系统的需求.
研究的目的:
- 评估使用两个可植入的离心心 HeartWare HVAD 作为双心室辅助系统的可行性.
- 评估这种新方法对双心脏衰竭患者的安全性和有效性.
主要方法:
- 十七名患有末期心力衰竭的患者接受了两台HeartWare HVAD的植入.
- 一个作为左心室辅助装置,第二个作为右心室辅助装置.
- 对右心室辅助装置进行了修改,以优化性能,包括增加后负载和减少输入管长度.
主要成果:
- 修改后的右心室辅助装置有效运行,提供3.0-5.5L/分钟.
- 30天生存率为82%,其中59%的患者被送回家.
- 没有观察到任何患者有临床意义的血液溶解.
结论:
- 两个HeartWare HVAD可以成功地被用作可植入的双心室辅助系统.
- 与传统的大型排水相比,这种方法为患者提供了更好的舒适性和流动性.
- 这一策略代表了对治疗双心室性心力衰竭的有前途的进展.
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