在患有双大动脉的患者中发生大动脉并发症的发生率
Hector I Michelena1, Amber D Khanna, Douglas Mahoney
1Division of Cardiovascular Disease, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. michelena.hector@mayo.edu
JAMA
|September 16, 2011
概括
双主动脉 (BAV) 患者的主动脉解剖发生率较低,但明显高于一般人群. 长期数据显示,BAV患者的大动脉动脉瘤和手术风险增加.
科学领域:
- 心脏病学 心脏病学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 双动脉 (BAV) 是最常见的先天性心脏缺陷.
- 对BAV患者大动脉并发症的长期,基于人群的数据有限.
研究的目的:
- 为了确定AVB患者中大动脉并发症的发生率.
- 将这些发病率与一般人口进行比较.
主要方法:
- 对奥姆斯特德县居民被诊断患有BAV (1980-1999年) 的回顾性队列研究.
- 长期随访 (2008年至2009年) 评估胸前大动脉解剖,上升大动脉动脉瘤和大动脉手术.
- 包括已诊断和未诊断的BAV患者.
主要成果:
- 在BAV患者中,大动脉剖析发生率为每1万患者年3.1%,比一般人群高8.4倍.
- 上升大动脉动脉瘤的发病率为每1万患者年中有84.9,比一般人群高86.2倍.
- 在BAV患者中,大动脉手术的25年率为25%.
结论:
- 在BAV患者中,大动脉剖析的发生率较低,但与普通人群相比显著增加.
- BAV患者面临着发展大动脉动脉瘤并需要大动脉手术的风险大幅增加.
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