合成乙胆的T细胞在迷走神经电路中中继神经信号
Mauricio Rosas-Ballina1, Peder S Olofsson, Mahendar Ochani
1Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA.
概括
迷走神经是迷走神经的一部分.
科学领域:
- 神经免疫学 神经免疫学
- 自主神经系统的自主神经系统
- 具有天生的免疫力.
背景情况:
- 炎症反射,一个迷走神经电路,抑制瘤亡因子-α,以防止炎症.
- 这种反射需要通过巨细胞上的α7尼古丁性乙胆受体传递乙胆信号.
- 脏神经纤维缺乏产生乙胆的酶,这就提出了关于反射的胆性机制的问题.
研究的目的:
- 为了研究迷走神经的炎症反射以胆固醇信号终结的机制.
- 为了确定神经介导的免疫抑制中涉及的乙胆的来源.
主要方法:
- 利用小鼠模型研究细胞因子产生的神经调节.
- 研究了T细胞在炎症反射中的作用.
- 在漫游神经刺激过程中检查了中乙胆的产生和信号传递.
主要成果:
- 确定了一种特定的记忆表型T细胞,产生乙胆的特定群体.
- 证明这些产生乙胆的T细胞对于炎症反射是必不可少的.
- 证明迷走神经刺激调节这些T细胞以抑制细胞因子的产生.
结论:
- 迷走神经中的动作潜能激活T细胞产生乙胆.
- 这种T细胞衍生的乙胆对于通过炎症反射控制先天免疫反应至关重要.
- 揭示了一种新的途径,神经系统通过T细胞介导的胆固醇信号传递来调节免疫力.
相关概念视频
Cholinergic Neurons: Neurotransmission
Cholinergic neurotransmission involves the synthesis and the release of acetylcholine (ACh) in order to transmit nerve impulses across the synapse. The process begins with the synthesis of acetyl CoA, a precursor for ACh, from ATP, acetate, and coenzyme A in the mitochondria. Choline, another vital precursor, is transported inside the neuron through choline transporters, including high-affinity choline transporter CHT1, low-affinity choline transporter CTL1, and lower-affinity choline...
Classification of Neurotransmitters
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
Parasympathetic Signaling
Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
The effects of...
Neurotransmitters
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

