驱动与 piriform 神经元组合相反的行为
Gloria B Choi1, Dan D Stettler, Benjamin R Kallman
1Department of Neuroscience and the Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Cell
|September 20, 2011
概括
皮质皮质可以产生学习的行为,即使没有感官输入. 特定的神经元组,当被激活并与奖励或冲击配对时,会引起不同的行为反应,证明皮质.
科学领域:
- 神经科学是一个神经科学.
- 嗅觉系统研究研究 嗅觉系统研究
- 行为神经科学 行为神经科学
背景情况:
- 人们认为,嗅觉至关重要的皮质皮质需要感官输入来表示气味.
- 现有的模型表明,气味的意义是通过经验来学习的.
研究的目的:
- 调查激活特定的皮质神经元群是否可以在没有感官输入的情况下诱导学习的行为.
- 为了确定不同的神经元子群是否可以独立控制以引起不同的学习反应.
主要方法:
- 在动物中,光遗传激活道罗多普辛表达 (ChR2) 皮质神经元.
- 将神经元激活与食欲 (奖励) 或厌恶 (冲击) 刺激进行配对.
- 测试区分和吸引不同神经元子群的能力,以获得不同的行为输出.
主要成果:
- 激活特定的皮质皮质神经元亚群,当与奖励或冲击配对时,可靠地引起食欲或厌恶行为.
- 证明不同的神经元子群可以独立控制,产生不同的学习行为.
- 显示皮质皮质足以产生学习的行为输出,而无需同时进行感官刺激.
结论:
- 皮质皮质可以独立于直接的感官输入产生学习的行为输出.
- 学习的嗅觉行为可以通过有针对性的激活特定的皮质皮质神经元组合来引起.
- 这些发现挑战了皮质皮质仅依赖于空间组织来识别气味和行为输出映射的模型.
相关概念视频
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01:13Nonconscious Mimicry
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01:11Direct Motor Pathways
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01:14Motor and Sensory Areas of the Cortex
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Motor Areas
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01:22Indirect Motor Pathways
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