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一个单链DNA/pyrrolobenzodiazepine添加物的观察

Khondaker M Rahman1, Colin H James, Tam T T Bui

  • 1Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK.

Journal of the American Chemical Society
|September 21, 2011
PubMed
概括

罗二zepines (PBDs) 抗瘤剂与单链DNA形成稳定的附加物,出乎意料地需要双重解离. 这些新型的PBD-DNA添加物表现出了显著的稳定性,即使没有小槽环境.

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