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选择性原甲基转移酶DOT1L抑制剂:设计,合成和结晶学研究

Yuan Yao1, Pinhong Chen, Jiasheng Diao

  • 1Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.

Journal of the American Chemical Society
|September 23, 2011
PubMed
概括

研究人员开发出强大的DOT1L抑制剂,对细胞分化和白血病至关重要,具有高选择性. 这些新型化合物作为化学探针来研究DOT1L在健康和疾病中的作用.

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