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Updated: May 29, 2026

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潜在的CCR5小分子对手化合物设计,使用组合突变发生/建模方法

Markus Metz1, Elyse Bourque, Jean Labrecque

  • 1Department of Medicinal Chemistry, Genzyme Corporation, 153 Second Avenue, Waltham, Massachusetts 02451, USA.

Journal of the American Chemical Society
|September 28, 2011
PubMed
概括

新的CCR5全抑制剂被开发用于打击病毒耐药性. 这项研究成功设计了具有低hERG抑制的强效抗病毒化合物,解决了慢性药物管理的关键需求.

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相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.