先天性心脏缺陷和发育和其他精神疾病:丹麦全国的队列研究
Morten Olsen1, Henrik Toft Sørensen, Vibeke E Hjortdal
1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark. mo@dce.au.dk
Circulation
|September 28, 2011
概括
患有先天性心脏缺陷 (CHD) 的患者患精神疾病的风险增加. 这种风险在女性中更高,并且与喘或糖尿病等其他疾病相比,较早出现.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 先天性心脏缺陷 (CHD) 影响心脏发育.
- 精神疾病是一个重大的公共卫生问题.
- 心血管疾病和精神疾病之间的关联需要进一步调查.
研究的目的:
- 调查丹麦患有先天性心脏缺陷 (CHD) 的患者精神病医院住院和门诊诊所的风险.
- 为了比较心脏病患者和普通人群之间的精神病发病率.
- 探索基于年龄,性别和其他疾病存在的风险的潜在差异.
主要方法:
- 使用了丹麦国家患者登记册和丹麦精神病中心登记册.
- 鉴定了6927名1977年至2002年间出生的CHD患者.
- 将心血管疾病患者与10名人口对比队列成员匹配,并调整父母因素.
主要成果:
- 在15年后,心脏病患者的精神病医院入院/访问的累积风险为5.9%.
- 在年轻的冠状动脉疾病患者中,精神病诊所的危险比率 (HRs) 较高 (男性:1.8,女性:2.5).
- 在CHD患者中观察到精神病风险增加,无论干预措施或并发症如何,发病时间比糖尿病/喘队伍更早.
结论:
- 患有先天性心脏病的患者面临精神疾病的风险增加,包括发育问题.
- 这种增加的风险存在,即使有或没有侵入性治疗或其他缺陷.
- 与糖尿病或喘患者相比,心脏病患者的这些精神疾病的发病时间较早.
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