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1型糖尿病患者的心肌结构,功能和痕
Evrim B Turkbey1, Jye-Yu C Backlund, Saul Genuth
1National Institutes of Health Clinical Center, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD 20892, USA.
Circulation
|September 28, 2011
概括
高血糖和1型糖尿病中的并发症与心脏结构变化和痕组织有关. 这些发现突显了糖尿病患者的关键心血管疾病风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 1型糖尿病 (T1DM) 与心血管疾病 (CVD) 风险增加有关.
- 了解T1DM对心脏结构和功能的影响对于风险分层至关重要.
- DCCT/EDIC研究为研究这些关系提供了一个独特的长期队列.
研究的目的:
- 检查T1DM患者心脏病风险因素与心肌结构,功能和痕之间的关联.
- 确定有助于T1DM心脏变化的特定危险因素.
- 评估T1DM队列中心肌痕的患病率.
主要方法:
- 心脏磁共振成像 (CMR) 在1017名T1DM患者中进行.
- 在741名患者中获得了加多增强的CMR.
- 线性和逻辑回归模型分析了心血管疾病风险因素和CMR参数之间的关联.
主要成果:
- 麦克罗白蛋白尿与左心室质量增加和左心室质量与终端透缩体积比较高有关.
- 超过22年的平均血红蛋白A1c升高与减少的终端透缩体积和中风体积有关,并增加左心室质量与终端透缩体积的比率.
- 通过CMR,心肌痕的患病率为4.3%;宏蛋白尿和平均血红蛋白A1c升高都与心肌痕显著相关.
结论:
- 升高的平均血红蛋白A1c和宏蛋白尿是T1DM心脏结构和功能变化的显著预测因素.
- 除了传统的心血管疾病风险因素之外,这些因素也会影响心肌健康.
- 该研究在T1DM患者中发现心肌痕的患病率为4.3%,功能相对保持良好.
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