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Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
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形状感应抗体稳定了PTP1B的氧化形式,并抑制了其酸酶活性

Aftabul Haque1, Jannik N Andersen, Annette Salmeen

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Cell
|October 4, 2011
PubMed
概括

研究人员开发了新型抗体来稳定蛋白氨酸酸酶1B (PTP1B) 的非活性形式,通过增强胰岛素信号传递,为糖尿病和肥胖提供了新的治疗策略.

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