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Artificial RNA Polymerase II Elongation Complexes for Dissecting Co-transcriptional RNA Processing Events
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由CTCF促进的RNA聚合酶II暂停将DNA甲基化与拼接联系起来

Sanjeev Shukla1, Ersen Kavak, Melissa Gregory

  • 1Center for Cancer Research, Mouse Cancer Genetics Program, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA.

Nature
|October 4, 2011
PubMed
概括

CCCTC结合因子 (CTCF) 蛋白通过调节RNA聚合酶II暂停来影响替代拼接. 基因甲基化可以改变CTCF结合,影响外子包容,并提供对拼接结果的表观遗传控制.

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