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Updated: May 28, 2026

In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
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2: 1 昆多林-c-MYC G-四重复的溶液结构:对G-四重复互动小分子药物设计的洞察

Jixun Dai1, Megan Carver, Laurence H Hurley

  • 1College of Pharmacy, University of Arizona, 1703 East Mabel Street, Tucson, Arizona 85721, United States.

Journal of the American Chemical Society
|October 5, 2011
PubMed
概括

基因促进体中的DNAG四重复,如c-MYC,是基因沉默的关键. 药物与这些结构的结合揭示了新的口袋,并为促进者向疗法提供了合理的药物设计指南.

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