复发性尿路感染的发生后性抗菌预防. 一个随机的,双盲的,安慰剂控制的试验
A Stapleton1, R H Latham, C Johnson
1Department of Medicine, University of Washington, Seattle.
JAMA
|August 8, 1990
概括
结合后的抗生素预防与trimethoprim-sulfamethoxazole显著减少了年轻女性的复发性尿路感染. 这种安全有效的治疗方法提供了一种廉价的方法来管理频繁的尿路感染.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 复发性尿路感染 (UTI) 在年轻女性中很常见.
- 建议进行性交后排泄,但抗生素预防是一种替代的管理策略.
研究的目的:
- 评估结交后抗生素预防在预防健康年轻女性中复发性尿路感染的疗效.
主要方法:
- 一个随机的,双盲的,安慰剂控制的研究.
- 27名妇女接受了trimethoprim-sulfamethoxazole或安慰剂,经过6个月的治疗.
- 群体在人口统计和性活动方面相似.
主要成果:
- 与安慰剂 (3.6 /患者年) 相比,trimethoprim-sulfamethoxazole显著降低了尿路感染率 (0.3 /患者年).
- 在不同的性交频率中观察到有效性.
- 报告了非常好的合规性和很少的副作用.
结论:
- 阴道后的三甲-硫甲醇是一种安全,有效和廉价的方法,用于管理年轻女性的复发性尿路感染.
- 这种预防策略无论性活动水平如何,都是有益的.
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