诊断和预防慢性代移植损失
Brian J Nankivell1, Dirk R J Kuypers
1Department of Renal Medicine, University of Sydney, Westmead Hospital, Sydney, NSW, Australia. brian_nankivell@wsahs.nsw.gov.au
Lancet (London, England)
|October 18, 2011
概括
接受移植的接受者面临着移植功能障碍和因免疫和非免疫原因的损失的风险. 早期监测和有针对性的干预措施对于保持功能和改善长期移植生存至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
背景情况:
- 移植是末期功能衰竭的最佳治疗方法.
- 移植功能障碍和损失可能导致死亡率和发病率增加.
研究的目的:
- 为了回顾代移植功能障碍的原因.
- 概述诊断和管理策略,以保护移植功能.
主要方法:
- 关于全移植功能障碍的免疫和非免疫原因的文献综述.
- 讨论监测,诊断调查和治疗干预措施.
- 强调积极的预防措施和翻译研究.
主要成果:
- 常见的威胁包括排斥,氨酸抑制剂毒性,缺血-再输液损伤,复发性疾病和BK病毒.
- 连续功能监测有助于早期发现功能障碍.
- 干预措施包括调整免疫抑制和管理并发性疾病.
结论:
- 及时诊断和有针对性的治疗对于管理脏全移植功能障碍至关重要.
- 控制高血压,蛋白尿,糖尿病和其他风险因素可以改善长期的移植存活率.
- 翻译性研究对于提高移植功能和寿命至关重要.
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