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Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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非规范性炎症酶激活的目标是caspase-11

Nobuhiko Kayagaki1, Søren Warming, Mohamed Lamkanfi

  • 1Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA. kayagaki@gene.com

Nature
|October 18, 2011
PubMed
概括

卡斯帕酶-11对于通过激活卡斯帕酶-1和产生IL-1β.通过激活卡斯帕酶-1和产生IL-1β.启动对细菌感染的先天免疫反应至关重要. 失去了caspase-11可以保护小鼠免受致命的内毒素冲击.

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