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Updated: May 28, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
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Published on: October 28, 2019

基于图像的全基因组siRNA屏幕识别了选择性自因子

Anthony Orvedahl1, Rhea Sumpter, Guanghua Xiao

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9113, USA.

Nature
|October 25, 2011
PubMed
概括

研究人员使用全基因组屏幕确定了控制哺乳动物选择性自的关键基因. 发现SMURF1蛋白对于清除病毒和受损的线粒体至关重要,突出其在细胞防御和器官质量控制中的作用.

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Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...