催化苏苏基-米亚乌拉反应的化
Mamoru Tobisu1, Tian Xu, Toshiaki Shimasaki
1Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan. tobisu@chem.eng.osaka-u.ac.jp
Journal of the American Chemical Society
|October 26, 2011
概括
新的催化方法有效地将化和酸 Ester 结合在一起. 这些协议使用金属化物或指导组激活具有挑战性的C-F键,扩大了有机化学中的合成可能性.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 合成方法论 合成方法论
背景情况:
- 烯化物在药品和材料中普遍存在,但具有挑战性的功能.
- 交叉合反应是形成C-C键的重要工具.
- 强大的基C-F键的有效激活仍然是一个重要的合成障碍.
研究的目的:
- 开发新的催化协议,用于化的交叉合.
- 为了使Suzuki-Miyaura反应与多种类型的烯化物.
- 研究催化中的C-F键激活机制.
主要方法:
- 开发两个不同的催化交叉合协议.
- 使用金属化物辅助催化剂 (例如ZrF{4},TiF{4}) 进行一般的化物合.
- 在化上使用正正导体组,以通过循环金属化促进C-F键的激活.
- 选N-异环 (皮里丁,烯,皮拉,氧化) 作为指导组.
- 替代剂对合伙伴的影响的系统研究.
主要成果:
- 通过金属化物辅助催化剂,成功合了缺电子和化芳类化物.
- 通过在化上使用N-异环导向组来证明有效的交叉合.
- 广泛的基质范围包括子, Ester,CF 3),基,基,甲,甲和基诺林.
- 与各种有机玻尿酸 Ester 成功结合.
- 获得了对催化化交叉合的机械洞察力.
结论:
- 已经建立了两个有效的协议,用于催化基化的苏苏基-米亚乌拉合.
- 开发的方法显著扩大了化在交叉合反应中的效用.
- 了解替代物效应为CF债券激活机制提供了基本的见解.
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