失眠和急性心肌梗塞的风险:一个人口研究
Lars E Laugsand1, Lars J Vatten, Carl Platou
1Department of Public Health, Faculty of Medicine, Trondheim, Norway. lars.e.laugsand@ntnu.no
Circulation
|October 26, 2011
概括
失眠症状如睡眠困难或非恢复性睡眠适度增加急性心肌梗塞 (AMI) 的风险. 这种关联是剂量依赖的,在所有分析中都是强大的.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 有限的前性研究存在于失眠和冠心病风险.
- 失眠是一种普遍存在的睡眠障碍,具有潜在的心血管影响.
研究的目的:
- 调查失眠症状与急性心肌梗塞 (AMI) 风险之间的关联.
- 评估失眠症状频率与AMI风险之间的剂量依赖关系.
主要方法:
- 一项大型基于人口的队列研究,涉及52,610名参与者.
- 在11.4年的时间里,使用医院记录和死亡登记册对事件AMI的随访.
- 多变量分析调整了许多心血管风险因素和生活方式变量.
主要成果:
- 失眠症状,包括难以开始睡眠,维持睡眠和非恢复性睡眠,与AMI风险的适度增加有关.
- 在失眠症状数量和AMI风险之间观察到剂量依赖的关联 (P趋势=0.003).
- 开始睡眠的困难与AMI风险 (HR=1.45) 有着特别强大的关联.
结论:
- 失眠是急性心肌梗塞的重要危险因素.
- 解决失眠症状对于心血管疾病预防策略可能很重要.
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