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Localization of Plasma Membrane and Intracellular Neuronal Nicotinic Acetylcholine Receptors Using Quantitative Imaging in Mammalian Cells
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神经毒素II与原生膜中的乙胆受体结合,通过动态核极化NMR研究

Arne H Linden1, Sascha Lange, W Trent Franks

  • 1Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125 Berlin, Germany.

Journal of the American Chemical Society
|November 2, 2011
PubMed
概括

这项研究证明了动态核极化 (DNP) NMR用于结构分析膜蛋白,如尼古丁酸乙胆受体 (nAChR) 没有净化. 优化的二基分布提高了研究本地膜中受体-连接体相互作用的灵敏度.

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