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美国实体器官移植接受者癌症风险的范围
Eric A Engels1, Ruth M Pfeiffer, Joseph F Fraumeni
1National Cancer Institute, 6120 Executive Blvd, EPS 7076, Rockville, MD 20892, USA. engelse@exchange.nih.gov
JAMA
|November 3, 2011
概括
固体器官移植接受者面临癌症风险翻倍,32种恶性瘤的发病率增加,包括非霍奇金淋巴瘤和肺癌,肝癌和癌. 这凸显了对移植群体持续癌症监测的必要性.
科学领域:
- 移植免疫学 移植免疫学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 固体器官移植接受者由于免疫抑制和瘤性病毒感染,患癌症的风险更高.
- 以前的研究主要集中在接受者身上,因此需要在不同类型的器官移植中进行更广泛的研究.
研究的目的:
- 为了全面描述固体器官移植后癌症发病率的整体模式.
- 在移植接受者中识别具有高风险的特定恶性瘤.
主要方法:
- 一项队列研究利用美国移植受体科学注册 (1987-2008) 和13个州/地区癌症注册的相关数据.
- 标准化发病率 (SIRs) 和过度绝对风险 (EARs) 被计算出来,以将移植受体的癌症风险与一般人群进行比较.
主要成果:
- 这项研究分析了175,732例固体器官移植 (脏,肝脏,心脏,肺).
- 总体癌症风险升高 (SIR,2.10),32种恶性瘤的风险增加,包括非霍奇金淋巴瘤,肺癌,肝癌和癌.
- 具体风险因器官类型而异,肺接受者的肺癌和肝接受者的肝癌显著增加.
结论:
- 实体器官移植接受者与普通人群相比,患有广泛的感染相关和无关癌症的风险增加.
- 这些发现强调了针对移植受体量身定制的癌症监测和预防策略的重要性.
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