超稳定,可再分散,小,和高度有机改性介质二氧化纳米治疗药物
Yu-Shen Lin1, Nardine Abadeer, Katie R Hurley
1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Journal of the American Chemical Society
|November 5, 2011
概括
稳定,可再分散的半孔化纳米颗粒克服了生物医学用途的聚合问题. 这些微小的纳米颗粒具有低毒性,有效地输送多克索鲁比,增强癌细胞治疗.
科学领域:
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
背景情况:
- 半孔二氧化纳米粒子 (MSNs) 在生物环境中面临聚合挑战,限制了它们的实际生物医学应用.
- 缺乏分散性和稳定性阻碍了MSNs在药物输送和其他体内用途中的有效性.
研究的目的:
- 为改进生物医学应用开发高度稳定和可再分散的半孔性二氧化纳米粒子.
- 解决微粒分散性差和MSNs在生物介质中不可逆转的聚合的局限性.
主要方法:
- 通过水热处理和双有机表面修饰合成小尺寸的MSN.
- 使用包括TEM,XRD,N2吸附-脱附,DLS,泽塔电位和固态29SiNMR在内的技术进行表征.
- 在模拟体液中评估稳定性,在干燥后重新分散性,以及体外毒性测试.
主要成果:
- 合成的MSN在模拟体液中表现出极好的稳定性,可以干燥和轻松重新分散,保持大小超过15天.
- 制备方法可以适应创建光和磁性MSN.
- 实验室试验显示毒性最小,多克索鲁比载的MSN对HeLa细胞呈现增强的细胞毒性.
结论:
- 高稳定性和可再分散性MSN为克服生物医学应用中的聚合问题提供了有希望的解决方案.
- 这些纳米粒子可以有效地装载和输送水溶性和水溶性差的药物,从而改善治疗结果.
- 开发的MSNs显示了未来体内生物医学应用的巨大潜力,包括向癌症治疗.
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