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Updated: May 27, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Published on: February 6, 2019

通过催化剂控制的立体选择性环闭转化合成宏环自然产品

Miao Yu1, Chenbo Wang, Andrew F Kyle

  • 1Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.

Nature
|November 5, 2011
PubMed
概括

这项研究引入了一种新的基于的环闭转化酶 (RCM) 催化剂,该催化剂精确控制类立体化学. 这一突破使复杂的宏环分子的高度立体选择性合成成为可能,改善了天然产品的合成.

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