深度的人类血统揭示了一个选择性的优势,在一个不断扩大的波浪前线上
Claudia Moreau1, Claude Bhérer, Hélène Vézina
1Centre de Recherche, Hôpital Sainte-Justine, Université de Montréal, 3175 Côte Sainte-Catherine, Montréal, Québec, Canada.
概括
人类人口扩张的动态显示,在扩大范围前线的祖先对基因库的贡献更大. 这与波浪前线女性的生育率更高有关,这是一个遗传特征.
科学领域:
- 人口遗传学 人口遗传学
- 人类进化人类的进化.
- 人口统计历史历史
背景情况:
- 人类在全球的殖民化涉及复杂的人口流程.
- 了解人口范围扩张的驱动因素仍然是进化生物学中的一个关键挑战.
研究的目的:
- 调查统治人类范围扩张的人口流程.
- 重建北克历史人口扩张的空间和遗传动态.
主要方法:
- 分析了超过一百万个人的家谱数据.
- 使用历史人口统计数据重建空间扩张动态.
- 基于位置 (范围前与核心) 的现代基因库的祖先贡献的比较.
主要成果:
- 今天的萨格内拉克-圣日恩人口中的大多数来自扩张波前线的祖先.
- 范围前的祖先对当前的基因库作出了不成比例的贡献.
- 波浪前线的女性表现出大约20%更高的有效生育率,这是一个遗传性特征.
结论:
- 生命历史特征,如生育能力,在范围扩张期间演变.
- 相对于扩张前线的空间位置显著影响了祖先对基因库的贡献.
- 范围前的人口结构过程在塑造人口遗传多样性方面发挥着至关重要的作用.
相关概念视频
Gene Flow
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
Gene Evolution - Fast or Slow?
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
Gene Duplication and Divergence
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are characterized.
Genetic Drift
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
Genome Size and the Evolution of New Genes
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.


